Epilepsy & Nutrition

Epilepsy and Carnosine Therapy

This chronic disease belongs to those conditions where oxidative stress and carbonylation damage the brain cells. Carnosine effectively fights these reactions, and is therefore apt as a dietary supplement for these patients (Petroff et al. 2000; 2001, Nguimfack Mbodie 2002).

MEDLINE data base includes at this writing 24 documents on the relationship between carnosine and epilepsy. If you want to read them, search for "carnosine; epilepsy", and click "go".

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Epilepsy References

1. Schlanger S, Shinitzky M, Yam D. Diet enriched with omega-3 fatty acids alleviates convulsion symptoms in epilepsy patients. Epilepsia 2002;43(1):103-4 (Medline)

2. Xiao Y, Li X. Polyunsaturated fatty acids modify mouse hippocampal neuronal excitability during excitotoxic or convulsant stimulation. Brain Research 1999;846(1):112-21 (Medline)

3. Blondeau N, Widmann C, Lazdunski M, Heurteaux C. Polyunsaturated fatty acids induce ischemic and epileptic tolerance. Neuroscience. 2002;109(2):231-41 (Medline)

4. Martin DS, Lonergan PE, Boland B ym. Apoptotic Changes in the Aged Brain Are Triggered by Interleukin-1beta -induced Activation of p38 and Reversed by Treatment with Eicosapentaenoic Acid. J Biol Chem. 2002 Sep 13;277(37):34239-46 (Medline)