Carnosine - Muscle ageing, muscle disorders
When man ages from 20 to 70 years of age, the lean body mass (muscles) decline by 20 %, and muscular strength and endurance decline likewise. The carnosine concentration and the antioxidant effect of carnosine decreases by half as age increases. This marked reduction in muscle carnosine concentration may be a cause of the age-related decline in muscle mass, strength and endurance.
The active, strong so-called fast muscle fibres contain much carnosine, while weak and atrophied fibres contain little. The Russian scientist Severin observed already in the 1950´s that addition carnosine to the liquid where exhausted isolated from muscle was incubated, immediately restored the full muscle energy. The Australian tea, led by Dr MacFarlane, has recently shown that supplementation with carnosine increases the strength and endurance of tired muscles. The more you take carnosine, the higher is the content in your muscles.
Carnosine has a role in the following neuromuscular disorders, too:
- ALS (amyotrophic lateral sclerosis)
- Duchenne´s muscle dystrophy
- myastenia gravis (MG),
- polymyositis
- medicine-related muscle diseases (e.g., statins)
- late-onset-mitochondrial myopathy.
The role of carnosine in neuromuscular diseases has been investigated scientifically, and the results suggest supplementation with carnosine. While carnosine does not cure these grave disorders, it halts the oxidative stress and may increase the contractility of the muscles and add some strength and endurance.
Patients with Duchenne´s dystrophy have only half of the normal carnosine content in their muscles. Therefor it seems pertinent to recommend carnosine as a supplement.
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